AMU faculty discovers common mechanism to prevent liver cancer

Hifzur Rahman Siddique of Department of Zoology, Aligarh Muslim University (AMU), in coordination with Dr Keigo Machida, University of South California have discovered a mechanism that activates disruption of a single RNA binding protein, MSI-2 binding to mRNAs of the cancer-causing proteins and significantly reduces the synthesis and accumulation of these proteins, reducing HCV infection and proliferation

In a major breakthrough in the field of cancer prevention, a common mechanism has been discovered that activates disruption of a single RNA binding protein, MSI-2 binding to mRNAs of the cancer-causing proteins and significantly reduces the synthesis and accumulation of these proteins, reducing HCV infection and proliferation.

Hifzur Rahman Siddique of Department of Zoology, Aligarh Muslim University (AMU), in coordination with Dr Keigo Machida, University of South California have discovered the mechanism. The single RNA binding protein (named MSI-2) helps to accumulate multiple cancer-causing proteins in patients and helps to proliferate Hepatitis C Virus to promote liver cancer.

Siddique and the team who have identified this protein by analysing the liver tissues of 374 liver cancer patients, said, "As we know, alcohol and cholesterol-rich high-fat diet and hepatitis infection promotes cancer initiation, but the exact molecular mechanism is unknown. In this research work, we have discovered that MSI-2 protein helps to accumulate multiple cancer-causing proteins and supports HCV proliferation to aggravate the disease."

Dr Siddique said that Liver hyperplasia is also reduced in the animal model predisposed to viral infection fed with alcohol mixed cholesterol-rich high-fat diet. This is a very exciting discovery and could serve as a potential therapeutic target for the drug design and give direction to the management strategy for this deadly disease. "The study has been recently published in Cell Death Discovery (April 2023, available at www.nature.com/cddiscovery)," he added. Dr Siddique and his team had earlier discovered the molecular pathway that promotes the abnormal division of cancer stem cells that are responsible for cancer therapy failure and Cancer reappearance/recurrence. Their study was then published in the prestigious journal Nature Communications 11 (2020).

He said that the liver is considered the powerhouse of the body and due to the change in lifestyle, chronic alcohol consumption, high-fat diet, and hepatitis virus infection, the incidence of liver cancer is increasing fast.